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Pregled bibliografske jedinice broj: 195632

Molecular Recognition Theory of the complementary (antisense) peptide interactions

Štambuk, Nikola; Konjevoda, Paško; Boban-Blagaić, Alenka; Pokrić, Biserka
Molecular Recognition Theory of the complementary (antisense) peptide interactions // Theory in biosciences, 123 (2005), 4; 265-275 (međunarodna recenzija, članak, znanstveni)

Molecular Recognition Theory of the complementary (antisense) peptide interactions

Štambuk, Nikola ; Konjevoda, Paško ; Boban-Blagaić, Alenka ; Pokrić, Biserka

Theory in biosciences (1431-7613) 123 (2005), 4; 265-275

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Molecular; recognition; antisense; peptide; RNA

Molecular Recognition Theory is basedon the finding of Blalock et al. (Biochem. Biophys. Res. Commun. 121 (1984) 203-207 ; Nature Med. I (1995)876-878 ; Biochem. J. 234 (1986) 679-683) that peptides specified by the complementary RNAs bind to each other with higher specificity and efficacy. This theory is investigated considering the interaction of the sense peptides coded by means of messenger RNA (read in 5' -3' direction) and antisense peptides coded in 3' -5' direction. We analysed the hydropathy of the complementary amino acid pairs and their frequencies in 1 0 peptide-receptor systems with verified ligand-receptor interaction. An optimization procedure aimed to reduce the number of possible antisense peptides derived from the sense peptide has been proposed. Molecular Recognition Theory was also validated by an "in vivo" experiment. It was shown that 3' -5' peptide antisense of (X-MSH abolished its cytoprotective effects on the gastric mucosa in rats. Molecular Recognition Theory could be useful method to simplify experimental procedures, reduce the costs of the peptide synthesis, and improve peptide structure modelling.

Izvorni jezik

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti


Projekt / tema

Institut "Ruđer Bošković", Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

Uključenost u ostale bibliografske baze podataka:

  • Chemical Abstracts
  • Excerpta Medica
  • Medline