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Pregled bibliografske jedinice broj: 195418

Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma


Pećina-Šlaus, Nives; Kljaić, Milka; Nikuševa-Martić, Tamara
Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma // Pathology, research and practice, 201 (2005), 8/9; 557-563 doi:10.1016/j.prp.2005.07.001 (međunarodna recenzija, članak, znanstveni)


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Naslov
Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma

Autori
Pećina-Šlaus, Nives ; Kljaić, Milka ; Nikuševa-Martić, Tamara

Izvornik
Pathology, research and practice (0344-0338) 201 (2005), 8/9; 557-563

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
APC gene; CDH1 gene; squamous cell carcinoma of the larynx; loss of heterozygosity

Sažetak
The molecular mechanisms involved in development and progression of laryngeal cancer, specifically squamous cell carcinoma, still need further investigation and elucidation. Twenty-two laryngeal squmous cell carcinomas were analyzed in our study regarding genetic changes of two tumor suppressor genes: Adenomatous polyposis coli (APC) and E-cadherin (CDH1). APC gene instability was tested by polymerase chain reaction/loss of heterozygosity (LOH) using Restriction Fragment Length Polymorphism (RFLP) method. The samples were also screened for mutations by heteroduplex method. E-cadherin gene was analyzed by PCR amplification of tetranucleotide marker (D16S752) linked to E-cadherin gene. The results of our analysis showed 3 samples with LOH of the APC gene out of 15 heterozygous patients (20%). Only one LOH of the CDH1 gene (5.5%) out of 18 heterozygous patients was discovered. D16S752 marker did not reveal any Replication error positive samples. There were 6 samples showing heteroduplexes (33%) encompased in APC's exon 11. Our results suggest that alterations of APC gene may have a role in squamous cell carcinoma development and progression. Detected LOH of the E-cadherin gene indicates that genetic changes of this gene are not very frequent, but that other components of the wnt signalling cascade may also be involved.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0108215

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Pećina-Šlaus, Nives; Kljaić, Milka; Nikuševa-Martić, Tamara
Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma // Pathology, research and practice, 201 (2005), 8/9; 557-563 doi:10.1016/j.prp.2005.07.001 (međunarodna recenzija, članak, znanstveni)
Pećina-Šlaus, N., Kljaić, M. & Nikuševa-Martić, T. (2005) Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma. Pathology, research and practice, 201 (8/9), 557-563 doi:10.1016/j.prp.2005.07.001.
@article{article, year = {2005}, pages = {557-563}, DOI = {10.1016/j.prp.2005.07.001}, keywords = {APC gene, CDH1 gene, squamous cell carcinoma of the larynx, loss of heterozygosity}, journal = {Pathology, research and practice}, doi = {10.1016/j.prp.2005.07.001}, volume = {201}, number = {8/9}, issn = {0344-0338}, title = {Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma}, keyword = {APC gene, CDH1 gene, squamous cell carcinoma of the larynx, loss of heterozygosity} }
@article{article, year = {2005}, pages = {557-563}, DOI = {10.1016/j.prp.2005.07.001}, keywords = {APC gene, CDH1 gene, squamous cell carcinoma of the larynx, loss of heterozygosity}, journal = {Pathology, research and practice}, doi = {10.1016/j.prp.2005.07.001}, volume = {201}, number = {8/9}, issn = {0344-0338}, title = {Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinoma}, keyword = {APC gene, CDH1 gene, squamous cell carcinoma of the larynx, loss of heterozygosity} }

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  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
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  • MEDLINE


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