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izvor podataka: crosbi

No association of CCR5D32 gene mutation with multiple sclerosis in Croatian and Slovenian patients (CROSBI ID 113702)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ristić, Smiljana ; Lovrečić, Luca ; Brajenović-Milić, Bojana ; Starčević-Čizmarević, Nada ; Šega Jazbec, Saša ; Barac-Latas, Vesna ; Vejnović, Danilo ; Sepčić, Juraj ; Kapović, Miljenko ; Peterlin, Borut No association of CCR5D32 gene mutation with multiple sclerosis in Croatian and Slovenian patients // Multiple sclerosis, 12 (2006), 3; 360-362. doi: 10.1191/135248506ms1305sr

Podaci o odgovornosti

Ristić, Smiljana ; Lovrečić, Luca ; Brajenović-Milić, Bojana ; Starčević-Čizmarević, Nada ; Šega Jazbec, Saša ; Barac-Latas, Vesna ; Vejnović, Danilo ; Sepčić, Juraj ; Kapović, Miljenko ; Peterlin, Borut

engleski

No association of CCR5D32 gene mutation with multiple sclerosis in Croatian and Slovenian patients

Several studies investigating the role of the CCR5D32 mutation in multiple sclerosis (MS) have reported varied, often contradictory results. Therefore in the present study we have analysed whether the CCR5D32 mutation is associated with the risk of/or disease process in Croatian and Slovene MS patients. 325 MS patients and 356 healthy controls were genotyped by polymerase chain reaction method. Our results showed no significant differences in the distribution of CCR5D32 mutations between MS and control subjects indicating that this mutation does not influence susceptibility to MS. Furthermore, we did not observe that CCR5D32 carrier-status could modulate age of disease onset or progression of the disease. It is therefore our conclusion that the present study indicates that the CCR5D32 mutation is neither protective of, nor a risk factor for MS development.

multiple sclerosis; CCR5 polymorphism; susceptibility gene

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

12 (3)

2006.

360-362

objavljeno

1352-4585

10.1191/135248506ms1305sr

Povezanost rada

nije evidentirano

Poveznice
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