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izvor podataka: crosbi

Expression of neutral glycosphingolipids in cytokine-stimulated human endothelial cells (CROSBI ID 113697)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Zemunik, Tatijana ; Markotić, Anita ; Marušić, Ana Expression of neutral glycosphingolipids in cytokine-stimulated human endothelial cells // Biochemistry Moscow, 69 (2004), 5; 513-519-x

Podaci o odgovornosti

Zemunik, Tatijana ; Markotić, Anita ; Marušić, Ana

engleski

Expression of neutral glycosphingolipids in cytokine-stimulated human endothelial cells

We compared immunohistochemical distribution of glycosphingolipids globotriosylceramide (GbOse(3)Cer) and globotetraosylceramide (GbOse(4)Cer) with that of E-selectin on human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor (TNF)-alpha. HUVECs activated by TNF-alpha were characterized by the highest expression of E-selectin and greatest adhesion of HL-60 cells as well compared to stimulation with interleukin-1beta or lipopolysaccharide. HUVECs activated by TNF-alpha also stained intensely with globoside antibodies, especially with the GbOse(3)Cer-directed one, staining being redistributed in a concentration-dependent manner. These results indicate the possible role of GbOse(3)Cer and GbOse(4)Cer in immune effector mechanisms of endothelium such as adhesion.

endothelium; glycosphingolipids; E-selectin; TNF-alpha; immunohistochemistry

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Podaci o izdanju

69 (5)

2004.

513-519-x

objavljeno

0006-2979

Povezanost rada

Kemija, Temeljne medicinske znanosti

Indeksiranost