engleski

Synthesis of biologically active 2, 4-diamino-5-benzylpyrimidine derivatives

The method of preparing biologically active derivatives of 2, 4-diamnio-5-benzylpyrimidines has been described, i.e. bacteriostatic trimethoprim and coccidiostatics diaveridine and ormethoprim. These compounds are prepared by catalytic hydrodehalogenation of their 6-chloroderivatives. Four synthetic pathways are shown which start from the corresponding derivatives of barbituric, 2-imino-, 4-imino- and 2, 4-diiminobarbituric acid and use acetylation, chlorination and ammonolysis reactions.

Active pyrimidines; Catalytic hydrodehalogenation; 6-Chloro pyrimidine derivatives

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