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Substituted 5-(3, 4, 5-trimethoxybenzyl)-barbiturates. Synthesis and antibacterial activity (CROSBI ID 113664)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Glunčić, Berislav ; Jakovina, Miroslav ; Kovačević, Krunoslav ; Kujundžić, Nedjeljko Substituted 5-(3, 4, 5-trimethoxybenzyl)-barbiturates. Synthesis and antibacterial activity // Acta Pharmaceutica Jugoslavica, 36 (1986), 393-404

Podaci o odgovornosti

Glunčić, Berislav ; Jakovina, Miroslav ; Kovačević, Krunoslav ; Kujundžić, Nedjeljko

engleski

Substituted 5-(3, 4, 5-trimethoxybenzyl)-barbiturates. Synthesis and antibacterial activity

By condensation of ethyl esters of 3, 4, 5-trimethoxybenzyl-malonic acid and - cyanoacetic acid with urea, guanidine, thiourea or N-methylurea, the corrersponding derivatives of barbituric, iminobarbituric, thiobarbituric and N-methylbarbituric acids have been synthesized. Their 5-alkyl and 5-allyl derivatives have also been prepared. The antibacterial activity of these compounds on the strains of animal and human origin has been tested. It has been found out that most of the compounds posses antibacterial activity similar to that of sulfaphenazole, the product used for comparison purposes. Dependence of antibacterial activity upon the structure of newly synthesized compounds has been discussed.

new barbituric acid derivatives ; antibacterial activity

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Podaci o izdanju

36

1986.

393-404

objavljeno

0001-6667

Povezanost rada

Kemija

Indeksiranost