engleski

Pleomorphic liposarcoma of the foot : a case report

Liposarcomas are among the most common soft tissue sarcomas of adult life. They often appear in lower parts of extremities and retroperitoneal, but are rarely found in the foot or ankle. Liposarcomas clinically presents as palpable, poorly defined, slow growing tumor mass. Their morphologic hallmarks are lipoblasts. Immunohistochemicaly those cells are positive for S-100 protein. Pleomorphic liposarcoma is rarely found in the foot or ankle. Only 2, 7% of all liposarcomas occur in the foot. To our knowledge only one case of pleomorphic liposarcoma of the foot is reported (Nishimoto et al.). Of 16 reported cases of liposarcoma, the most common type was myxoid (6 cases), not reported histological type (8 cases), well differentiated (1 case), and poorly differentiated (1 case). We present a case of a pleomorphic liposarcoma of the foot in a 71-year old female. She presented with a large mass on the dorsum of her right foot that had been gradually increasing in size over the past months, after a reported injury two years before. On physical examination firm, palpable tumor mass was 6-7 cm in diameter, poorly-defined from surrounding tissue and attached to underlying structures and skin. The biopsy specimen revealed bundles of tumor cells with pleomorphic, bizarre nuclei showing cytoplasmic vacuoles and scattered lipoblasts. Mitotic figures were frequent. Immunohistochemicaly tumor cells were positive for vimentin and S-100 protein, negative for desmin, myoglobulin and smooth-muscle actin. These findings indicated that the tumor was a pleomorphic liposarcoma. The surgeon performed below the knee amputation.

pleomorphic liposarcoma; foot; case report

nije evidentirano