engleski

IL1beta -511 promoter polymorphism and GEP-NET

Neuroendocrine tumors of the gut and pancreas (GEP-NET) produce biogenic amines, peptides and chromogranins, especially chromogranine A (CgA). Increased IL1 levels have been described in patients with NET, suggesting a regulatory link with this inflammatory cytokine and its role in tumor growth and morphogenesis. IL1beta gene is mapped to chromosome 2q14 and a few polymorphisms associated with altered IL1beta production have been described. The aim of our study was to estimate allelic frequency for -511 promoter SNP in IL1beta gene in patients with GEP-NET. DNAs obtained from 30 GEP-NET patients and 150 unrelated healthy volunteers were genotyped for the IL1beta -511 SNP using real-time PCR TaqMan® ; ; ; ; ; SNP genotyping assay. There was statistically significant difference in the frequency of -511T allele associated with altered IL1beta production between healthy population and patients with GEP-NET. The association between other IL1beta polymorphisms and GEP-NET tumors has to be investigated in the future studies.

IL1beta; SNP; GEP-NET

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