engleski

Dopamine effects involve gastric, but not heart protection in restraint stress

A simultaneous comparison between the effects of dopamine (D) drugs on gastric and myocardial lesions (as yet known only from sepatate data) was carried out in Wistar rats (200 g) subjected to 6 h or 48 h restraint stress (RS). Investigatet agents (mg/kg b.w.) (D-agonists (AG) bromocriptine 10, amantadine 20, D-antagonists (AN) haloperidol 5, domperidone 5) were administred i.p. 1 h before RS. Unstressed rats (hellty control) were also used for comparison. Previously described metods (Sikiric et al., EJP 158, 61, 1988) as well as simple microscopical scoring system (score 0-4) were used for stomach/hart lession assassment. Results. Time-dependent worseing of stomach and hart lessions was noted in RS. 6 h. We demonstrated a strong protection for DAG, and for DAN an aggravation inhibited by cooadministration of DAG. Heart. No significant influence of any studied agent. Conclusion. Therfore based on parallel and simultaneus comparison as well as know actions of used grugs DAG or DAN, these data do not provide the clear evidence for a concurrent involment of D-mechanisms in gastric and myocardial lesions in RS in any studied period. However, in wiew of D influence on gastric RS-lesion, additional investigations are certainly needed to clarify this problem.

Dopamine; gastric; heart; protection; restraint stress

Digestive Diseases and Sciences (0163-2116) 35 (1990) (8) ; 8-8