hrvatski

Sinteza i biološka aktivnost kompleksa platine(II) s dietil-esterom kinolil-8-metilfosfonske kiseline

In connection with our interest in the complexes of aminophosphonate derivatives of potential biological and pharmacological importance, we report the synthesis, characterization and biological evaluation of platinum(II) complexes of diethyl ester of quinolyl-8-ylmethylphosphonic acid (8-dqmp). It was shown that complexes demonstrated distinct antitumor activity in some animal and human tumor cell lines, but showed no or only marginal antiviral activity in the examined DNA and RNA assay systems.

platinum(II) complex; aminophosphonate; antitumor activity; antiviral activity

nije evidentirano