engleski

Biochemical markers of bone turnover in dogs

Measurement of bone markers for assessment of bone metabolism in clinical veterinary practice is not fully established. The aim of this study was investigation of standard bone markers in dogs treated in outpatient clinic and their relationship to clinical data. Blood samples were obtained during routine diagnostic procedures in 89 dogs and the following bone markers measured in sera by commercial kits: bone alkaline phosphatase, osteocalcin, and carboxy-terminal telopeptide of type I collagen. Clinical data included age, body weight, sex, neutered or no-neutered status and diagnosis. The results showed a statistically significant and positive correlation between the measured bone markers osteocalcin and telopeptide (r=0, 408 ; p= 0, 0005), osteocalcin and bone alkaline phosphatase (r=0, 291 ; p=0, 006) and telopeptide and bone alkaline phosphatase (r= 0, 249 ; p= 0, 02). Correlation between osteocalcin and age was statistically significant and negative (r=- 0, 315 ; p=0, 003), and positive between telopeptide and body weight (r= 0, 325 ; p= 0, 002). No difference for bone markers existed between sexes or diagnosis groups, i.e. between control animals, bone-related diseases and other conditions. The observed association between bone formation and resorption markers confirmed coupling of bone cell actions. Osteocalcin decrease with age revealed changes of skeletal growth, and the positive relationship of telopeptide with body weight indicated the impact of muscle mass on bone turnover. Utilisation of bone marker measurement in veterinary medicine could be considered for evaluation of bone turnover and study of bone metabolism. Determination of bone markers for diagnostic purpose in dogs requires further investigation.

bone; biochemical markers; dogs

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