engleski

The significance of the gastroproductive effect of body protection compound (BPC): modulation by different procedures

To elucidate any mechanism of a body protecting effect the observed events should be investigated also by the way of their modulations induced by ablation of particular organs. For Body Protection Compound (BPC), a newly partially characterized gastric juice peptide, the gastroprotection has largly been studied in basal and modified conditions of 48 h-restraint stress. Ablations or sham operations have been performed before restraint as follows: 60 min vagotomy, 24 h ovaria, testes, spleen, 48 h medulla of adrenal glands, 40 days thyroid+parathyroid glands. BPC (10 microgram/kg) or saline (5 ml/kg) have been regulary applied (after surgery, 1 h before restraint) intraperitoneally. The group subjected to thyroparathyroidectomy recieved also once-daily BPC/saline treatment. Avery strong gastroprotective effect in basal conditions has been modulated by ovariectomy and demodullation (abolishment), thyroparathyroidectomy (decrease), and no change occured in case of vagotomy, splenectomy or orchidectomy. Sham operated rats did not differ from corresponding control. Thus, seeing from point of view a wide range of organoprotective effects of BPC (intestinum, kidney, liver, pancreas, inflammation, diabetes melitus, delayed type hypersensitivity), the gastroprotection has been suposed a) to be of crucial pattern in the general concept of organo-protection and b) to be responsible for the mediation of the suggested "stomach stress organoprotective response". Therefore, the obtained modulations suggest a complex and specifical, sex-related action of the overall beneficial affects of BPC.

body protection compound(BPC); stomach stress coping response; organ ablations; modulations; gastroprotection; rats

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