engleski

Apoptosis of pancreatic B-cells in alloxan treated rats

The alloxan toxicity concept has been based on its rapid and selective uptake by islet B-cells and their high sensitivity to alloxan formed peroxides. Since reaktive oxigen metabolites have been demonstrate to cause apoptotic cell death, the aim of this study was to investigate weather alloxan causes morphological picture of apoptosis rather than previously described necrosis. 48 hours after single sc. administration of 150 mg/kg of alloxan monohydrate, female Wistar rats developed severe hyperglicemia as well as B-cell loss. Histological analysis has demonstrated apoptosis, not necrosis, of B-cells in alloxan treated animals. No apoptotic cells were found in non treated aimals.

apoptosis; B-cell and alloxan

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