The development of PL 14736 for treatment of inflammatory bowel disease (CROSBI ID 506298)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Veljača, Marija ; Krnić, Žarka ; Brajša, Karmen ; Pavić-Sladoljev, Dubravka ; Mildner, Boris ; Ševeljević-Jaran, Daša ; Kolega, Marko ; Erceg, Damir ; Krznarić, Željko
engleski
The development of PL 14736 for treatment of inflammatory bowel disease
Pl 14736 is a 15 amino acid peptide of a unique sequence, a part of a larger molecule. Pharmacological activity of PL 14 736 has been tested in vitro and in vivo, revealing beneficial activity against experimental tissue damage. Since PL 14736 has shown potent protective and healing properties in the models of upper gastrointestinal tract lesions and in particular in acute and sub-acute models of colitis, this compound was taken to pursue pre-clinical development for IBD indication. In order to fulfill regulatory requirements for the conduct of the phase I study, all non-clinical safety studies were performed with PL 14736.
IBD; peptide non-clinical safety
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Podaci o prilogu
9-9.
2001.
objavljeno
Podaci o matičnoj publikaciji
Abstract book of the 3rd Congress of the Croatian Society of gastroenterology
Zagreb:
Podaci o skupu
Congress of the Croatian Society of gastroenterology (3 ; 2001)
poster
23.09.2001-26.09.2001
Zagreb, Hrvatska