engleski

Fibrinogen as a risk factor in patients with HITS

The aim of this study was to determine the relationship between plasma fibrinogen levels in patients with HITS and those without HITS. A total of 50 patients with a cardiac disease (recent myocardial infarction, myocardiopathy, atrial fibrillation, prosthetic heart valve, valvular stenosis or mural thrombi) was investigated. Plasma fibrinogen levels were determined in all patients and simultaneous TCD monitoring of both middle cerebral arteries was performed over 60 minutes. The patients were categorised into two groups: emboli positive and emboli negative, and according to weather they had or had not a prior neurological event. HITS were detected in 22 (44 percent) patients. The mean plasma fibrinogen level in emboli positive patients was significantly higher (3.66 g/L) than in emboli negative patients (3.14 g/L), (p less than 0.05). HITS can be detected in a large proportion of patients with cardiac diseases. Elevated plasma fibrinogen levels might be added to the list of risk factors for stroke and may serve as a predictor of future vascular events.

fibrinogen; cerebral microemboli; transcranial Doppler

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