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Pregled bibliografske jedinice broj: 192590

Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes


Župan, Gordana; Casamenti, Fiorella; Scali, Carla; Pepeu, Giancarlo
Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes // Pharmacology, biochemistry and behavior, 45 (1993), 1; 19-25 (međunarodna recenzija, članak, znanstveni)


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Naslov
Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes

Autori
Župan, Gordana ; Casamenti, Fiorella ; Scali, Carla ; Pepeu, Giancarlo

Izvornik
Pharmacology, biochemistry and behavior (0091-3057) 45 (1993), 1; 19-25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
immature rats; lesions of the nucleus basalis magnocellularis; choline acetyltransferase; passive avoidance conditioned response; postnatal recovery

Sažetak
Short- and long-term effects of unilateral lesions of the nucleus basalis magnocellularis (NBM) on cortical choline acetyltransferase (ChAT) activity and passive avoidance conditioned responses were examined in immature rats. The lesions were made by stereotaxic injection of quisqualic acid on postnatal days 14(P14), 17(P17) and 21(P21). A marked loss of ChAT activity was found 7 days after surgery in all age groups of lesioned rats. Unoperated P14 rats were unable to perform the passive avoidance conditioned responses. Acquisition began on P17. Lesions made on P17 and P21 strongly impaired the acquisition and retention of the task, evaluated 7 days postoperation. No biochemical but a partial behavioral recovery was observed 3 months after surgery in rats lesioned on P14. On the contrary, despite a persistent decrease in cortical ChAT activity, rats lesioned on P21 were able to acquire and retain the passive avoidance conditioned response. These results indicate that destruction of NBM cholinergic neurons shortly after birth is not compensated for by the developmental plasticity of the residual neurons but results in permanent cholinergic hypofunction. They also demonstrate that cholinergic NBM neurons play an important role in the acquisition and retention of a passive avoidance task ; nevertheless, a behavioral recovery may take place 3 months after the lesion, even in the presence of a persistent cholinergic hypofunction.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Gordana Župan (autor)


Citiraj ovu publikaciju:

Župan, Gordana; Casamenti, Fiorella; Scali, Carla; Pepeu, Giancarlo
Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes // Pharmacology, biochemistry and behavior, 45 (1993), 1; 19-25 (međunarodna recenzija, članak, znanstveni)
Župan, G., Casamenti, F., Scali, C. & Pepeu, G. (1993) Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes. Pharmacology, biochemistry and behavior, 45 (1), 19-25.
@article{article, year = {1993}, pages = {19-25}, keywords = {immature rats, lesions of the nucleus basalis magnocellularis, choline acetyltransferase, passive avoidance conditioned response, postnatal recovery}, journal = {Pharmacology, biochemistry and behavior}, volume = {45}, number = {1}, issn = {0091-3057}, title = {Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes}, keyword = {immature rats, lesions of the nucleus basalis magnocellularis, choline acetyltransferase, passive avoidance conditioned response, postnatal recovery} }
@article{article, year = {1993}, pages = {19-25}, keywords = {immature rats, lesions of the nucleus basalis magnocellularis, choline acetyltransferase, passive avoidance conditioned response, postnatal recovery}, journal = {Pharmacology, biochemistry and behavior}, volume = {45}, number = {1}, issn = {0091-3057}, title = {Lessions of the nucleus basalis magnocellularis in immature rats: short- and long-term biochemical and behavioral changes}, keyword = {immature rats, lesions of the nucleus basalis magnocellularis, choline acetyltransferase, passive avoidance conditioned response, postnatal recovery} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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