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Lecithin and arecolin improve passive avoidance behaviour in the nucleus basalis lesioned rats

The passive avoidance behaviour reduction was caused by bilateral electrolytic lesions of the nucleus basalis equivalent (NB) in rats. Intraperitoneal injection of cholinomimetics lecithin (3.2x10-4 mol.kg-1) and arecoline (6.4x10-6 mol.kg-1) significantly improved the passive avoidance in the NB lesioned rats. There is no significant difference between the effects of lecithin or arecoline or in combination.

nucleus basalis lesion; passive avoidance; lecithin; arecoline; rat

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