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Pregled bibliografske jedinice broj: 191971

A high rate of Down's syndrome in two regions of Croatia


Ligutić, Ivo; Barišić, Ingeborg; Švel, Ivo; Dolk, Helen; Beer, Zlata; Modrušan-Mozetič, Zlata; Capar, Marijan; Žužek, Adele
A high rate of Down's syndrome in two regions of Croatia // Paediatric and perinatal epidemiology, 8 (1994), 1; 120-122 doi:10.1111/j.1365-3016.1994.tb00440.x (međunarodna recenzija, pismo, znanstveni)


CROSBI ID: 191971 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A high rate of Down's syndrome in two regions of Croatia

Autori
Ligutić, Ivo ; Barišić, Ingeborg ; Švel, Ivo ; Dolk, Helen ; Beer, Zlata ; Modrušan-Mozetič, Zlata ; Capar, Marijan ; Žužek, Adele

Izvornik
Paediatric and perinatal epidemiology (0269-5022) 8 (1994), 1; 120-122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
Down syndrome; Croatia; high rate

Sažetak
In the light of concern about possible environmental influences on Down's syndrome incidence, we would like to bring to attention a high rate of Down's syndrome in Croatia. Since 1983, the Zagreb EUROCAT registry of congenital anomalies has been operating in Croatia, covering geographically defined populations in the cities of Rijeka and Varaždin since 1983 (5% of births in Croatia) and extending to the region of Varaždin and Istria since 1986 (bringing coverage up to 9% of births in Croatia). Comparison of rates of Down's syndrome with other EUROCAT registries, and an analysis over time, showed an unusually high rate of Down's syndrome. This was first noticed in 1987 for data up to 1986, and has continued in subsequent surveillance to 1988. More recent data are not yet available. As induced abortions following prenatal diagnosis, which we do not register among cases in Croatia, complicate comparisons for older mothers, we restricted further analysis to younger mothers (less than 30 years of age) and liveborn cases. We calculated the expected number of cases using the average EUROCAT rates for the age groups <20, 20-24 and 25-29 applied to the maternal age distribution of the study population for each year. There were twice as many cases observed than expected (O/E=2.1, 95% CI 1.5-2.9). This increase seems to be particularly strong in the time period 1986-1988, and perhaps for the extension of the registration region. All cases have been verified with respect to maternal residence and karyotype. Only one diagnosis had no karyotype confirmation. We do not believe this increase to be related to Chernobyl, not only because the irradiation of the Croatian population would be unlikely to cause a detectable increase in Down's syndrome, but also because all of the cases in 1986 were conceived before the accident, and thus the phenomenon seems to predate Chernobyl. Investigation continues, but we would be most interested to hear of other investigations of Down's syndrome clusters.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Opća bolnica Varaždin

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Ligutić, Ivo; Barišić, Ingeborg; Švel, Ivo; Dolk, Helen; Beer, Zlata; Modrušan-Mozetič, Zlata; Capar, Marijan; Žužek, Adele
A high rate of Down's syndrome in two regions of Croatia // Paediatric and perinatal epidemiology, 8 (1994), 1; 120-122 doi:10.1111/j.1365-3016.1994.tb00440.x (međunarodna recenzija, pismo, znanstveni)
Ligutić, I., Barišić, I., Švel, I., Dolk, H., Beer, Z., Modrušan-Mozetič, Z., Capar, M. & Žužek, A. (1994) A high rate of Down's syndrome in two regions of Croatia. Paediatric and perinatal epidemiology, 8 (1), 120-122 doi:10.1111/j.1365-3016.1994.tb00440.x.
@article{article, author = {Liguti\'{c}, Ivo and Bari\v{s}i\'{c}, Ingeborg and \v{S}vel, Ivo and Dolk, Helen and Beer, Zlata and Modru\v{s}an-Mozeti\v{c}, Zlata and Capar, Marijan and \v{Z}u\v{z}ek, Adele}, year = {1994}, pages = {120-122}, DOI = {10.1111/j.1365-3016.1994.tb00440.x}, keywords = {Down syndrome, Croatia, high rate}, journal = {Paediatric and perinatal epidemiology}, doi = {10.1111/j.1365-3016.1994.tb00440.x}, volume = {8}, number = {1}, issn = {0269-5022}, title = {A high rate of Down's syndrome in two regions of Croatia}, keyword = {Down syndrome, Croatia, high rate} }
@article{article, author = {Liguti\'{c}, Ivo and Bari\v{s}i\'{c}, Ingeborg and \v{S}vel, Ivo and Dolk, Helen and Beer, Zlata and Modru\v{s}an-Mozeti\v{c}, Zlata and Capar, Marijan and \v{Z}u\v{z}ek, Adele}, year = {1994}, pages = {120-122}, DOI = {10.1111/j.1365-3016.1994.tb00440.x}, keywords = {Down syndrome, Croatia, high rate}, journal = {Paediatric and perinatal epidemiology}, doi = {10.1111/j.1365-3016.1994.tb00440.x}, volume = {8}, number = {1}, issn = {0269-5022}, title = {A high rate of Down's syndrome in two regions of Croatia}, keyword = {Down syndrome, Croatia, high rate} }

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