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Intronic Polymorphism of Tryptophan Hxdroxylase and Serotonin Transporter: Indication for Combined Effect in Predisposition to Suicid (CROSBI ID 505932)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Jernej, Branimir ; Štefulj, Jasminka ; Hranilović, Dubravka ; Balija, Melita ; Kubat, Milovan Intronic Polymorphism of Tryptophan Hxdroxylase and Serotonin Transporter: Indication for Combined Effect in Predisposition to Suicid // Book of Abstracts / Ambriović Ristov, Andreja ; Brozović, Anamarija (ur.). Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2003. str. 48-48-x

Podaci o odgovornosti

Jernej, Branimir ; Štefulj, Jasminka ; Hranilović, Dubravka ; Balija, Melita ; Kubat, Milovan

engleski

Intronic Polymorphism of Tryptophan Hxdroxylase and Serotonin Transporter: Indication for Combined Effect in Predisposition to Suicid

Recent epidemiological studies revealed the role of genetic factors in the predisposition to sucide, which is now considered a disorder sui generis, independent of concomitant psychiatric disorder. Indices of disturbed serotonergic neurotransmission are the most robust biological findings in suicide. Serotonergic neurotransmission is controlled by two main mechanisms: synthesis of the transmitter, regulated by the rate limiting tryptophan hydroxylase (TPH), and termination of transmission, mediated by 5-hydroxytryptamine transporter (5HTt). Intronic polymorphisms have been identified in both TPH (218AC in intron 7) and 5HTt (VNTR, with 12 and 10 repeats) genes. In the present work, we investigated whether the concurrence of two suspected, allegedly transcriptionally less active, variants (TPH allele C and 5HTt allele 10) represented the increased risk for suicidal behavior.

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Podaci o prilogu

48-48-x.

2003.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstracts

Ambriović Ristov, Andreja ; Brozović, Anamarija

Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu

Podaci o skupu

2nd Scientific Symposium With International Participation

poster

20.11.2003-21.11.2003

Zagreb, Hrvatska

Povezanost rada

Temeljne medicinske znanosti