Intronic Polymorphism of Tryptophan Hxdroxylase and Serotonin Transporter: Indication for Combined Effect in Predisposition to Suicid (CROSBI ID 505932)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Jernej, Branimir ; Štefulj, Jasminka ; Hranilović, Dubravka ; Balija, Melita ; Kubat, Milovan
engleski
Intronic Polymorphism of Tryptophan Hxdroxylase and Serotonin Transporter: Indication for Combined Effect in Predisposition to Suicid
Recent epidemiological studies revealed the role of genetic factors in the predisposition to sucide, which is now considered a disorder sui generis, independent of concomitant psychiatric disorder. Indices of disturbed serotonergic neurotransmission are the most robust biological findings in suicide. Serotonergic neurotransmission is controlled by two main mechanisms: synthesis of the transmitter, regulated by the rate limiting tryptophan hydroxylase (TPH), and termination of transmission, mediated by 5-hydroxytryptamine transporter (5HTt). Intronic polymorphisms have been identified in both TPH (218AC in intron 7) and 5HTt (VNTR, with 12 and 10 repeats) genes. In the present work, we investigated whether the concurrence of two suspected, allegedly transcriptionally less active, variants (TPH allele C and 5HTt allele 10) represented the increased risk for suicidal behavior.
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Podaci o prilogu
48-48-x.
2003.
objavljeno
Podaci o matičnoj publikaciji
Book of Abstracts
Ambriović Ristov, Andreja ; Brozović, Anamarija
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu
Podaci o skupu
2nd Scientific Symposium With International Participation
poster
20.11.2003-21.11.2003
Zagreb, Hrvatska