engleski

Estrogen receptor (ER) in breast cancer tissue of premenopausal patients: are some ER- findings false due to down-regulation?

Estrogen receptor (ER) and progesterone receptor (PR) status at the time of breast carcinoma surgery is used as a marker of both prognosis and hormone dependency to guide adjuvant therapy [1]. This approach is based on the accumulated knowledge that the presence of estrogen and/or progesterone receptors typically suggests slower-growing tumors, amenable to hormonal manipulation [2]. In most clinical studies and therapy recommendations, breast cancer is considered hormone dependent if at least one receptor type is present in the tumor tissue.

breast neoplasms ; estrogen receptors ; down-regulation

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