engleski

Serum lipid concentrations in Croatian veterans with post-traumatic stress disorder, post-traumatic stress disorder comobid with major depressive disorder, or major depressive disorder

The aim of this study was to asses eventual differences in serum cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, LDL-C/HDL-C ratio between veterans with combat-related Post-traumatic stress disorder (PTSD) only or comorbid with major depressive disorder (MDD), veterans with combat experiences with MDD, and healthy control group. PTSD and /or MDD were diagnosed according to structured clinical interview based on DSM-IV criteria. Additional criteria to diagnosed PTSD were Clinician Administered PTSD Scale (CAPS), and to diagnosed MDD Montgomery-Asberg Depression Rating Scale (MADRAS). Serum lipid concentrations were determined by using the enzyme-assay method. Veterans with combat-related PTSD as well as veterans with combat-related PTSD comorbid with MDD showed significantly higher concentrations of cholesterol (F=9.858, p<0.01), triglycerides (F=10.112, p<0.01), LDL-C (F=11.145, p<0.01), and LDL-C/HDL-C ratio (F=8.346, p<0.01) vs. veterans with MDD or healthy control group. Contrary healthy control group and veterans with MDD showed significantly higher concentrations of HDL-C (F=8.421, p<0.01), vs. veterans with PTSD or PTSD comorbid with MDD. In conclusion, there are no differences in serum lipids concentrations between veterans with combat-related PTSD and PTSD comorbid with MDD, but they have higher lipids concentrations than veterans with MDD or healthy control subjects.

Croatia; cholesterol; low-density lipoproteins; high-density lipoproteins; triglycerides; post-traumatic stress disorder; major depressive disorder

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