Detection and characterization of measles virus strains in cases of subacute sclerosing panencephalitis in Croatia (CROSBI ID 112715)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Forčić, Dubravko ; Baričević, Marijana ; Zgorelec, Renata ; Kružić, Vladimira ; Kaić, Bernard ; Marušić Della Marina, Branka ; Cvitanović Šojat, Ljerka ; Tešović, Goran ; Mažuran, Renata
engleski
Detection and characterization of measles virus strains in cases of subacute sclerosing panencephalitis in Croatia
Two cases of subacute sclerosing panencephalitis (SSPE), diagnosed in Croatia in 2002, were investigated. The coding regions of the matrix (M), hemagglutinin (H) and nucleoprotein (N) genes of measles virus were sequenced following direct RT-PCR amplification of viral RNA extracted from brain tissue. Phylogenetic analysis of the sequences of H and N genes, showed that both strains belonged to genotype D6. No vaccine strain was detected although both patients had been previously immunized. The comparison of analyzed sequences of two SSPE causative viruses with corresponding sequences of D6 genotype and with each other revealed a number of mutations in N and H gene sequences. In comparison to the Edmonston reference strain, the M gene of the SSPE viruses showed the characteristic biased hypermutation and a premature termination codon in one of the patients.
SSPE; Measles genotype; Mutations
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Biologija