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Pregled bibliografske jedinice broj: 189909

The enantiomeric recognition of dihydropyrimidonic compounds by chiral selectors derived from from 4- or 2-chloro-3, 5-dinitrobenzoic acid


Gazić, Ivana; Kontrec, Darko; Lesac, Andreja; Vinković, Vladimir
The enantiomeric recognition of dihydropyrimidonic compounds by chiral selectors derived from from 4- or 2-chloro-3, 5-dinitrobenzoic acid // Tetrahedron: asymmetry, 16 (2005), 6; 1175-1182 doi:10.1016/j.tetasy.2005.01.042 (međunarodna recenzija, članak, znanstveni)


Naslov
The enantiomeric recognition of dihydropyrimidonic compounds by chiral selectors derived from from 4- or 2-chloro-3, 5-dinitrobenzoic acid

Autori
Gazić, Ivana ; Kontrec, Darko ; Lesac, Andreja ; Vinković, Vladimir

Izvornik
Tetrahedron: asymmetry (0957-4166) 16 (2005), 6; 1175-1182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chiral Stationary Phase ; HPLC ; 2- or 4-Chloro-3 ; 5-dinitrobenzoic Acid ; Dihydropyrimidones

Sažetak
Six new chiral packing materials for high performance liquid chromatography were prepared from chiral selectors consist of 4- or 2-chloro-3, 5-dinitrobenzoic acid, L-alanine and different p-donor aromatic units. Comparative tests of newly prepared CSPs on separation efficacy for 13 racemic dihydropyrimidonic (DHPM) analytes has revealed the strong contribution of the p-acceptor branching unit, as well as the important influence of the structure of terminal p-donor unit. The role of terminal aromatic group is primarily to increase the rigidity of selector structure. Comparison of the data revealed that selectors bound on the silica gel could be preorganized during the process of chiral recognition, resulting in the similar enantioseparation properties for DHPM analytes on both type of CSPs. However, some other compounds, like aminoalcohol b-agonists, exhibit the very different enantioseparations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098050
0098051

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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