engleski

The enantiomeric recognition of dihydropyrimidonic compounds by chiral selectors derived from from 4- or 2-chloro-3, 5-dinitrobenzoic acid

Six new chiral packing materials for high performance liquid chromatography were prepared from chiral selectors consist of 4- or 2-chloro-3, 5-dinitrobenzoic acid, L-alanine and different p-donor aromatic units. Comparative tests of newly prepared CSPs on separation efficacy for 13 racemic dihydropyrimidonic (DHPM) analytes has revealed the strong contribution of the p-acceptor branching unit, as well as the important influence of the structure of terminal p-donor unit. The role of terminal aromatic group is primarily to increase the rigidity of selector structure. Comparison of the data revealed that selectors bound on the silica gel could be preorganized during the process of chiral recognition, resulting in the similar enantioseparation properties for DHPM analytes on both type of CSPs. However, some other compounds, like aminoalcohol b-agonists, exhibit the very different enantioseparations.

Chiral Stationary Phase ; HPLC ; 2- or 4-Chloro-3 ; 5-dinitrobenzoic Acid ; Dihydropyrimidones

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