engleski

Trisomy and tetrasomy of the long arm of chromosome 1 in a direct praparation of human endometrial adenocarcinoma

Chromosome banding analysis was performed on an endometrial adenocarcinoma. A minimal variety in the chromosome number and morphology was found. All analyzed pseudodiploid and aneuploid carcinoma cells had two chromosomes 1 of normal morphology and the presence of a marker of markers derived from chromosome 1. Tetrasomy of the long arm of chromosome 1 was found in 12 of 19 cells analyzed, accompanied by trisomy of the long arm of chromosome 1 in the rest of the cells. No other common chromosome marker was observed. Previously published data and our results suggest that trisomy and tetrasomy of the long arm of chromosome 1 may represent a specific karyotypic change in subtypes of endometrial adenocarcinoma.

chromosomes human pair 1; trisomy

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