engleski

Naphthalan in the treatment of patients with neurodermitis

Guided by the results of the study using naphthalan in the treatment of psoriasis (i.e. its antiinflammatory and antiproliferative effect), and stimulated by the satisfactory, months-long remissions in more than 70% of treated patients, we decided to examine the efficacy of naphthalan in the treatment of patients with atopic dermatitis. The study included 15 patients aged >15 with different clinical forms of atopic dermatitis. Naphthalan therapy has been applied for 3 weeks. During this period, the patients were taking baths in tubs containing naphthalan oil (temperature 34-38&ordm ; ; ; C) every day for 12-14 minutes. This is the usual therapy that has been practiced for 12 years in the treatment of patients with psoriasis and rheumatic disease. Besides naphthalan baths, the patients were also applying neutral cream and were administered oral antihistaminics. Evaluation of therapeutic results included clinical evaluation (photographs taken before and after the 3-week therapy) ; SCORAD Index (Severity scoring of atopic dermatitis)-before and after the 3-week therapy ; histologic evaluation ; total IgE ; and laboratory tests After the 3-week naphthalan therapy, all patients experienced improvement in the form of reduction or disappearance of itching and sleeping disorders. The mean SCORAD Index was 71.92 before therapy and 25.66 after the 3-week therapy. Histologic findings showed no signs consistent with atopic dermatitis. Standard laboratory analysis showed no values that would suggest nephrotoxicity, hematotoxicity or hepatotoxicity due to naphthalan oil.

naphthalan; antiinflammatory and antiproliferative effect

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