engleski

Gizzerozine induced histopathological changes in laying hens

Histopathological changes in organs of laying hens challenged with different doses of gizzerosine (2, 5 ; 5 ; 7, 5 ; 10 mg/kg b.w. daily during a three-week period) are described. The experiment was performed od 115 hens divided into five groups (Ko=10/no- tretment, K1/n =21/-tretment with saline, G1/n=21-2, 5 mg/kg b.w. of gizzerosine, G2/n=21-5mg/kg b.w., G3/n=21/7, 5 mg/kg b.w.). Gross changes were mainly noticed on gizzard with mild congestion, and reversible degenerative changes of the liver kidneys. Among the histopathological changes /heart, liver, kidney, splee, lungs, pancreas, brain, duodenum and proventriculus/ in the challenged groups the most prominent were blood vessel lesion (thickening and hyalinisation of the blood vessel walls , perivascular oedema and mononuclear parietal infiltration) especially in the lungs, brain spleen. Parenchymatous, as well as hydropic and vacuoalr degeneration due to hypoxia, were found in all examined tissues. The most prominent changes were in duodenum, where severe inflammation with necrosis was noted, while milder forms were characterized by the vacuolization of duodenal lamina propria. Pancreatic necroses were probably the consequence of direct toxicity of gizzerosine.

laying hens ; gizzerosine ; histopathological lesions ; subchronic changes

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