engleski

Adenomatoid Tumor of Fallopian Tube

Adenomatoid tumor is the most frequent benign primary tumor of Fallopian tube. Usually it has asymptomatic course and usually represent incidental finding during the routine pathomorphological examination of the adnexa. Today it is considered to be of mesothelial origin based on microscopic, ulrastructural and immunohistochemical analysis. 51-year old nullipara was admitted to Department of Gynecology and Obstetrics, "Sisters of Charity" University Hospital, because of the left ovarian single cyst, that was histologically determined as a simple ovarian cyst. The left Fallopian tube was 60 mm long and 5 mm wide containing well circumscribed round yellowish nodule of medium firm consistency measuring 6:5 mm., which was situated under tubal serosa and partially in the muscular layer of the tube. Tubal lumen was strongly displaced by the tumor. Histologically tumor was composed of many irregular clefts or tubular partially cystic dilated spaces covered mainly by flat to cubical epithelial-like cells. There were no blood cells in discribed spaces. An anastomosing fibrovascular partially hyalinized stromal network among tumor clefts and tubules was shown. Performed immunohistochemical analysis revealed the mesothelial immunophenotype of the tumor: expression of EMA as well as Cytokeratine 8 (LMW) were negative. Faint mosaically positive reaction of Cytokeratine MNF 116 (PAN) was observed. Expressions of CD34 and of FVIII antigens were negative in tumor cells, but positive in the vascular stroma. Expression of Vimentine was strongly positive and intense equally in the tumor cells as well as in the stroma. Presented adenomatoid tumnor of Fallopian tube represents incidental finding and its practical importance is in differential diagnosis versus primary tubal adenocarcinoma. These tumors may also be the cause of extrauterine gravidity.

Adenomatoid Tumor; Fallopian Tube; Pathohistology

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