engleski

Incidence of squamous metaplasia in transitional cell carcinoma of urinary bladder

Squamous metaplasia in transitional cell carcinoma of urinary bladder is considered as an adverse prognostic factor. These patients have weaker response on therapy and lower survival rate. In our study we used pathohistological data of 1781 patients operated for urinary bladder carcinoma in the Department of Urology of Sestre milosrdnice University Hospital during the period from 1989 to 2000. The aim of our study was to determine the incidence of squamous metaplasia in the bioptic material according to histologic grade and growth pattern. Squamous metaplasia was found in 5.7% of patients. According to growth pattern, this phenomenon is more frequent in patients with solid growth pattern. In papillary cancers, the higher incidence of squamous metaplasia was determined in G1 and G2 histologic grade, while in the solid growth pattern, the most of the cases with squamous metaplasia or over 80% were of G3 histologic grade. Muscle layer invasion was present in high percentage of both, papillary and solid urothelial cancers with squamous metaplasia, which imply the high malignant potential of cancers with foci of squamous metaplasia.

squamous metaplasia; transitional cell carcinoma of urinary bladder

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