engleski

Chronic relapsing experimental allergic encephalomyelitis in rats ; clinicopathological course, some genetical and immunological aspects

Experimental allergic encephalomyelitis was induced in rats of various genotypes by active immunization with an encephalitogenic bovine brain extract. Chronic relapsing clinical disease was noted in juvenile F1 progeny of Albino Oxford males and Dark August females in a high percentage of animals, 65-75% varying from series to series of experiments, and in Dark August strain in only 20-25% of animals. We report here the summary of clinicopathological, genetical and some immunological analyses F1 rats. Our results confirmed (1) the close similarities in morphology of central nervous system, lesions between chronic relapsing clinical disease and multiple sclerosis, (2) the essential role of cell-mediated immunity in the pathogenesis of experimental allergic encephalomyelitis, (3) the fact that experimental allergic encephalomyelitis susceptibility is a genetic trait, and (4) the existence of a defective systemic immune regulation in chronic relapsing clinical disease.

experimental allergic encephalomyelitis; rats

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