engleski

C3 komlement level in the blood of multiple sclerosis patients

C3 complement was followed in the blood of 68 patients, clinically definitive cases of multiple sclerosis (MS). Control groups included 16 healthy persons and 22 patients affected by other neurological noninflammatory diseases. Hypocomplementaemia (C3 values below 0, 95g/l) was found in 14 patients (20.6%), but only 9 of them had a persistent hypocomplementaemia. Conversely to data in the literature, the authors were unable to find any relatioship between hypocomplementaemia and the incidence of HLA-B18 antigen. Significantly lower complement values were found in groups of patients suffering from serious infections and having MS longer then 10 years. The patients with a higher disability score had a significantly higher level of the complement. The author's results do not support the wiew about hypocomplementaemic MS as a specific form of disease.

complement-C3-analysis; multiple sclerosis-immunology; blood-peripheral

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