Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 187635

AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT


Taradi, Milan; Urano, Muneyasu; Kukolja Taradi, Sunčana; Maruyama, Y.
AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT // International journal of hyperthermia, 7 (1991), 4; 653-665 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 187635 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT

Autori
Taradi, Milan ; Urano, Muneyasu ; Kukolja Taradi, Sunčana ; Maruyama, Y.

Izvornik
International journal of hyperthermia (0265-6736) 7 (1991), 4; 653-665

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
OK-432 (PICIBANIL); NATURAL KILLER CELLS; BIOLOGICAL RESPONSE MODIFIERS; MOUSE FIBROSARCOMA

Sažetak
It has previously been demonstrated that the local administration of OK-432 (Picibanil) enhances the response of a murine tumour and normal tissue to elevated temperatures. The experimental animals were C3Hf/Sed mice and the tumours were the fourth generation isotransplants of a spontaneous non-immunogenic fibrosarcoma, FSa-II. The thermal enhancement ratio was greater for the tumour than for normal tissue, resulting in a favourable differential effect between normal and malignant tissues. Further studies were conducted to disclose the mechanism of OK-432 induced thermal enhancement. Although OK-432 showed a slight direct cytotoxic activity against tumour cells in vitro, the in vivo antitumour effect of combined OK-432 and hyperthermia treatments was greater than the effect expected from in vitro cytotoxicity, indicating the involvement of the host-mediated mechanisms. Whole body irradiation (WBI), which suppressed the host's immune reaction, did not affect the thermal enhancement mediated by OK-432, suggesting that radiosensitive cells (sensitive to WBI) were not involved in this process. As expected, the i.v. injections of the anti-mouse T-cell serum did not have any effect on the thermal enhancement of OK-432. The administration of blockers of the reticuloendothelium system, i.e. silica or trypan blue, did not inhibit the OK-432 induced thermal enhancement. Moreover, local intratumoural injections of normal or OK-432 induced macrophages showed no effect on tumour growth. The thermal enhancement by OK-432 was eliminated following treatments with anti-(asialo GM1) globulin. Despite the fact that the cytotoxic effect of anti-(asialo GM1) globulin was not selective to natural killer (NK) cells, all the experimental results indicated that NK cells were probably attributable to thermal enhancement by OK-432 in vivo. The NK cell activity was stimulated when the OK-432 was locally administered with hyperthermia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108221

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Milan Taradi (autor)

Avatar Url Sunčana Kukolja-Taradi (autor)


Citiraj ovu publikaciju:

Taradi, Milan; Urano, Muneyasu; Kukolja Taradi, Sunčana; Maruyama, Y.
AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT // International journal of hyperthermia, 7 (1991), 4; 653-665 (međunarodna recenzija, članak, znanstveni)
Taradi, M., Urano, M., Kukolja Taradi, S. & Maruyama, Y. (1991) AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT. International journal of hyperthermia, 7 (4), 653-665.
@article{article, author = {Taradi, Milan and Urano, Muneyasu and Kukolja Taradi, Sun\v{c}ana and Maruyama, Y.}, year = {1991}, pages = {653-665}, keywords = {OK-432 (PICIBANIL), NATURAL KILLER CELLS, BIOLOGICAL RESPONSE MODIFIERS, MOUSE FIBROSARCOMA}, journal = {International journal of hyperthermia}, volume = {7}, number = {4}, issn = {0265-6736}, title = {AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT}, keyword = {OK-432 (PICIBANIL), NATURAL KILLER CELLS, BIOLOGICAL RESPONSE MODIFIERS, MOUSE FIBROSARCOMA} }
@article{article, author = {Taradi, Milan and Urano, Muneyasu and Kukolja Taradi, Sun\v{c}ana and Maruyama, Y.}, year = {1991}, pages = {653-665}, keywords = {OK-432 (PICIBANIL), NATURAL KILLER CELLS, BIOLOGICAL RESPONSE MODIFIERS, MOUSE FIBROSARCOMA}, journal = {International journal of hyperthermia}, volume = {7}, number = {4}, issn = {0265-6736}, title = {AUGMENTATION OF MOUSE NATURAL-KILLER-CELL ACTIVITY BY COMBINED HYPERTHERMIA AND STREPTOCOCCAL PREPARATION, OK-432 (PICIBANIL) TREATMENT}, keyword = {OK-432 (PICIBANIL), NATURAL KILLER CELLS, BIOLOGICAL RESPONSE MODIFIERS, MOUSE FIBROSARCOMA} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font