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Pregled bibliografske jedinice broj: 187632

Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil)


Urano, Muneyasu; Taradi, Milan; Kukolja Taradi, Sunčana
Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil) // International journal of hyperthermia, 7 (1991), 1; 113-123 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 187632 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil)

Autori
Urano, Muneyasu ; Taradi, Milan ; Kukolja Taradi, Sunčana

Izvornik
International journal of hyperthermia (0265-6736) 7 (1991), 1; 113-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
OK-432 ; natural killer cells ; mouse fibrosarcoma ; hyperthermia

Sažetak
We have studied the effect of a streptococcal preparation, OK-432, given alone or in combination with hyperthermia on murine tumour and normal tissues. The experimental tumour was a spontaneous non-immunogenic fibrosarcoma FSa-II transplanted in the foot of C3Hf/Sed mice. Local hyperthermia was achieved by immersing the mouse foot into a constant temperature water bath (42-45-degrees-C) for various lengths of time. Tumour response was studied by analysing the tumour growth (TG) time. Various doses of OK-432 (1-5 KE/mouse) were injected locally into the tumour. Local administration of OK-432 alone (without hyperthermia) had no effect on the TG time. Thermal enhancement ratio (TER) for combined treatment was independent of drug dose >/- KE, and the mean TER was 1.48 +/- 0.27 (95% CL). The TER was greater for 6 mm tumours than for 4 mm tumours, and it was greatest if the time interval between hyperthermia and drug administration was 3 h or less. There was no effect if the drug was administrated 4 days before hyperthermia, but its application 9 days prior to hyperthermia caused a slight prolongation of the TG time of non-heated tumours, and a reduction in the TG time of heated tumours. Normal-tissue response was studied by scoring the peak foot reaction and RD50 (the treatment time to induce a specified response in one-half of the treated animals). The effect of OK-432 on the thermal response of the foot was also studied at various temperatures. The mean TER was 1.11 +/- 0.07. Local administration of OK-432 failed to modify significantly the kinetics of thermotolerance. Present experiments demonstrated that OK-432 after local administration enhanced the thermal response of murine tumour and normal tissues. This enhancement was greater for the tumour than for the normal tissue, resulting in a favourable differential effect between normal and malignant tissues (the average therapeutic gain was 1.33 +/- 0.19).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108221

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Milan Taradi (autor)

Avatar Url Sunčana Kukolja-Taradi (autor)


Citiraj ovu publikaciju:

Urano, Muneyasu; Taradi, Milan; Kukolja Taradi, Sunčana
Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil) // International journal of hyperthermia, 7 (1991), 1; 113-123 (međunarodna recenzija, članak, znanstveni)
Urano, M., Taradi, M. & Kukolja Taradi, S. (1991) Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil). International journal of hyperthermia, 7 (1), 113-123.
@article{article, author = {Urano, Muneyasu and Taradi, Milan and Kukolja Taradi, Sun\v{c}ana}, year = {1991}, pages = {113-123}, keywords = {OK-432, natural killer cells, mouse fibrosarcoma, hyperthermia}, journal = {International journal of hyperthermia}, volume = {7}, number = {1}, issn = {0265-6736}, title = {Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil)}, keyword = {OK-432, natural killer cells, mouse fibrosarcoma, hyperthermia} }
@article{article, author = {Urano, Muneyasu and Taradi, Milan and Kukolja Taradi, Sun\v{c}ana}, year = {1991}, pages = {113-123}, keywords = {OK-432, natural killer cells, mouse fibrosarcoma, hyperthermia}, journal = {International journal of hyperthermia}, volume = {7}, number = {1}, issn = {0265-6736}, title = {Enhancement of the thermal response of murine tumour and normal tissues by a streptococcal preparation, OK- 432 (Picibanil)}, keyword = {OK-432, natural killer cells, mouse fibrosarcoma, hyperthermia} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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