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Pregled bibliografske jedinice broj: 1876

Comparing Mass Spectrometic Characteristics of Peptides and Peptoides

Heerma, W.; Versluis, C.; de Koster, C.G.; Kruijtzer, J.A.W.; Žigrović, Ivanka; Liskamp, R.M.J.
Comparing Mass Spectrometic Characteristics of Peptides and Peptoides // RCM. Rapid communications in mass spectrometry, 10 (1996), 4; 459-464 doi:10.1002/(SICI)1097-0231(19960315)10:43.0.CO ; 2-J (međunarodna recenzija, članak, znanstveni)

Comparing Mass Spectrometic Characteristics of Peptides and Peptoides

Heerma, W. ; Versluis, C. ; de Koster, C.G. ; Kruijtzer, J.A.W. ; Žigrović, Ivanka ; Liskamp, R.M.J.

RCM. Rapid communications in mass spectrometry (0951-4198) 10 (1996), 4; 459-464

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mass spectrometry ; peptides ; peptoides

The collision-induced dissociation (CID) spectra of the [M + H](+) ions of a pentapeptide and the corresponding peptoid and retropeptoid have been compared, The spectra of the peptide and peptoid both exhibit B- and Y-n-type sequence ions at identical m/z values. In contrast to the peptide, the [M + H](+) ion of the peptoid and all sequence ions containing an N-substituted glycine derivative corresponding to a tyrosine amino acid residue can easily lose a C7H6O molecule in a charge-remote fragmentation process, The presence of N-substituted glycine residues in a peptoid is further apparent from the presence of N-substituted immonium ions, which differ significantly in their fragmentation behaviour from the corresponding immonium ions observed in the spectra of common oligopeptides. Loss of the CH2=NH imine molecule is the dominant fragmentation reaction in the CID spectra of all peptoid immonium ions investigated in this study. The elimination of the CH=NH2 ylide analogue from common peptide immonium ions is energetically less favourable as shown by ab initio calculations. The relative heat of formation of the CH=NH2 ylide neutral appeared to be 168 kJ mol(-1) more than that of the CH2=NH inine molecule.

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Znanstvena područja


Projekt / tema

Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Ivanka Jerić, (218943)

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus