Napredna pretraga

Pregled bibliografske jedinice broj: 187137

Synthesis And Comparative Cytostatic Activity Of The New N-7 Acyclic Purine Nucleoside Analogues With Natural N-9 Regioisomers


Prekupec, Svjetlana; Kalokira, Blanka; Grdiša, Mira; Pavelić, Krešimir; De Clercq, Erik; Mintas, Mladen; Raić-Malić, Silvana
Synthesis And Comparative Cytostatic Activity Of The New N-7 Acyclic Purine Nucleoside Analogues With Natural N-9 Regioisomers // Heterocycles, 65 (2005), 787-796 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis And Comparative Cytostatic Activity Of The New N-7 Acyclic Purine Nucleoside Analogues With Natural N-9 Regioisomers

Autori
Prekupec, Svjetlana ; Kalokira, Blanka ; Grdiša, Mira ; Pavelić, Krešimir ; De Clercq, Erik ; Mintas, Mladen ; Raić-Malić, Silvana

Izvornik
Heterocycles (0385-5414) 65 (2005); 787-796

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acyclic Purine Nucleoside Analogues; Biological Evaluation; 1H and 13C NMR Spectra

Sažetak
The synthesis of the purine derivatives alkylated at N-7 (2a) and N-9 (2b) with 2-acetoxyethoxymethyl side chain, and chemical transformations of keto to chloro (5a), chloro to thio (6a) at C-6, and amino to fluoro (7a) at C-2 position of the purine ring were described. Structures of compounds were elucidated by analysis of their 1H and 13C NMR spectra, MS spectra and elemental analyses. N-7 Regioisomers (2a-7a) were evaluated for their cytostatic activities and their inhibitory effects were compared with those of the corresponding N-9 isomers. The 2-aminopurin-6-thione derivative (6a) showed the highest cytostatic activity, particularly against murine leukemia (L1210).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098093
0125003

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts