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Platelet function analysis in children with Schonlein-Henoch syndrome (CROSBI ID 111909)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Čulić, Srđana ; Jakl, Rudolf ; Metličić, Vitomir ; Pauković-Sekulić, Branka ; Rešić, Biserka ; Čulić, Vida ; Kuljiš, Dubravka ; Primorac, Dragan Platelet function analysis in children with Schonlein-Henoch syndrome // Archives of medical research, 32 (2001), 4; 268-272-x

Podaci o odgovornosti

Čulić, Srđana ; Jakl, Rudolf ; Metličić, Vitomir ; Pauković-Sekulić, Branka ; Rešić, Biserka ; Čulić, Vida ; Kuljiš, Dubravka ; Primorac, Dragan

engleski

Platelet function analysis in children with Schonlein-Henoch syndrome

Background. Schonlein-Henoch syndrome (SHS) or anaphylactic purpura in childhood is the result of pathologic and immunologic responses to different antigens. These antigens could induce the formation of immune complexes responsible for vasculitis and their precipitation on the endothelium of small blood vessels. Purpuric bruises, hematuria, hematemesis, melena, or hematohesis may suggest coagulation disturbances. Increasing bleeding tendency may suggest platelet function disturbance. To examine the qualitative function of platelets in children with SHS, we decided to analyze its aggregation function. Methods. Using the Born method of testing, we analyzed platelet aggregation in 24 children with SHS. Results. Based on the aggregograms examined, we observed that most patients had abnormal aggregation curves, in which platelets demonstrated a block of release of the endogenous ADP. with or without desaggregation. Conclusions. One clinical symptom of SHS appearing in most patients is a mild or in creased tendency toward bleeding. On measuring induced aggregation of platelets in children with SHS, we observed that the qualitative function of platelets was disturbed

Schonlein-Henoch syndrome; thrombocytopathia; childhood

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Podaci o izdanju

32 (4)

2001.

268-272-x

objavljeno

0188-4409

Povezanost rada

nije evidentirano

Indeksiranost