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Pregled bibliografske jedinice broj: 186593

Etoposide as the basic and interferon-alpha as the maintenance therapy for Langerhans cell histiocytosis: A rtc


Čulić, Srđana; Jakobson, A.; Čulić, Vida; Kuzmić, Ivana; Šćukanec-Špoljar, Mira; Primorac, Dragan
Etoposide as the basic and interferon-alpha as the maintenance therapy for Langerhans cell histiocytosis: A rtc // Pediatric hematology and oncology, 18 (2001), 4; 291-294 (međunarodna recenzija, članak, znanstveni)


Naslov
Etoposide as the basic and interferon-alpha as the maintenance therapy for Langerhans cell histiocytosis: A rtc

Autori
Čulić, Srđana ; Jakobson, A. ; Čulić, Vida ; Kuzmić, Ivana ; Šćukanec-Špoljar, Mira ; Primorac, Dragan

Izvornik
Pediatric hematology and oncology (0888-0018) 18 (2001), 4; 291-294

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Etoposide; INF-alpha; Langerhans cell histiocytosis

Sažetak
The treatment of patients who suffer from a disseminated form of Langerhans cell histiocytosis (LCH) is still controversial So far ; few larger randomized studies have been performed. The authors present 3 patients with a disseminated form of LCH-4 months, 9 months, and 2 years old, respectively. The lesional Langerhans cells in each patient showed positive immunohistochemical reaction to S-100 protein and the presence of Birbeck granules was confirmed by electron microscopy. All the patients were Created with etoposide (VP-16) 200 mg/m(2) for 3 consecutive days, with 15 cycles at intervals of 3 weeks between each cycle, followed by maintenance therapy with IFN-alpha. All 3 patients reached complete stabile remission. The patients were young, at high risk, with multiple-organ involvement of LCH, and two of them had obvious signs of organ dysfunction at presentation, suggesting a poor prognosis. All remain disease-free several years after therapy. The results suggest that INF-alpha may prevent recurrences in high-risk patients

Izvorni jezik
Engleski

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE