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Pregled bibliografske jedinice broj: 186583

Interferon-induced growth arrest is mediated by membrane structual changes


Guha, A.; Mason, R.P.; Primorac, Dragan; Konopaske, G.; Miller, J.; Sinha, P.; Tulenko, T.N.; Hand, A.
Interferon-induced growth arrest is mediated by membrane structual changes // Journal of interferon & cytokine research, 17 (1997), 11; 701-706 (međunarodna recenzija, članak, znanstveni)


Naslov
Interferon-induced growth arrest is mediated by membrane structual changes

Autori
Guha, A. ; Mason, R.P. ; Primorac, Dragan ; Konopaske, G. ; Miller, J. ; Sinha, P. ; Tulenko, T.N. ; Hand, A.

Izvornik
Journal of interferon & cytokine research (1079-9907) 17 (1997), 11; 701-706

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IFN-gamma; messenger-RNA; antigens; cells; biosynthesis; modulation; surface; alters

Sažetak
Interferon-gamma (IFN-gamma) is an immunomodulator shown to augment the expression of major histocompatibility (MHC) class I/class II antigens on the cell surface. In previous studies, we have demonstrated that the enhanced expression of these antigens on the cell surface is in part due to IFN-gamma-mediated abrogation of antigen shedding. In this study, me demonstrate that IFN-gamma induces structural changes in the cell membrane by altering the cholesterol/phospholipid ratio. Furthermore, such changes not only mediate enhanced expression of antigen on the cell surface but may drive the cells to growth arrest and apoptosis. These results were obtained by employing x-ray diffraction, electron microscopy, and DNA analysis.

Izvorni jezik
Engleski



POVEZANOST RADA


Autor s matičnim brojem:
Dragan Primorac, (212641)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE