engleski

Epidemiology of primary central nervous system tumors in the Coast and Gorski Kotar County, Croatia, 1977-2000

Aim and background: To establish the incidence of primary tumors of the central nervous system (CNS) in the resident population of the Coast and Gorski Kotar County, Croatia, in the period 1977-2000. Methods: A retrospective descriptive epidemiological study. Tumors were classified according to the World Health Organization's scheme. A total of 911 cases was identified. Information about patient gender and age at diagnosis, tumor location and histologic type was obtained from case histories, autopsy protocols and pathology reports. Age- and sex-adjusted incidence were determined by a direct standardization method. Results: Histologic confirmation was obtained in 84.5% of cases. The most frequent tumors were glioblastoma in men (30.2%) and meningioma in women (29.5%). The average annual crude and world-standardized incidence was 11.2 (95%CI, 10.1-12.3) and 8.2/100, 000/year (95%CI, 7.4-9.0), respectively. The highest specific age incidence was detected in the seventh decade of life, 24.7/100, 000/year (95% CI, 21.4-28.8). The tumors occurred equally in each year sex. The lowest incidence was detected on the islands, 7.4/100, 000/year (95% CI, 5.9-9.2) and the highest a long the coast, 12.7/100, 000/year (95% CI, 11.4-14.0). The survey showed the highest incidence of these neoplasms in the coastal municipality of Senj, 14.7/100, 000/year (95% CI, 10.3-20.5). Conclusion: The descriptive epidemiological incidence of primary CNS tumors in the Coast and Gorski Kotar County, Croatia, especially those of neuroepithelial and meningeal origin, correspond to the data reported in similar studies elsewhere in the world. The incidence of these neoplasms in the area investigated is uneven. Limitations in study design preclude definitive conclusions about the causes of these differences.

central nervous system primary tumors; Croatia; epidemiology

nije evidentirano