engleski

The immuno-regulatory cells involved in weakening of concomitant immunity

Concomitant immunity (CI) is a phenomenon of secondary tumour rejection during the primary tumour growth. We tested dynamic of development and weakening of CI to Ehrlich ascites tumour (EAT) and mammary carcinoma (MC) if both tumours (primary and secondary) grow subcutaneously (s.c.). Also we used MC artificial lung metastases to evaluate the influence of CI on the development of metastases in mice already carrying s.c. MC. CI attained its maximal intensity in any of these experiments around 9th day after primary tumour injection, but the intensity and duration of CI depended on dose of secondarily injected tumour cells and on experimental model. To analyse the role of different spleen cell populations in weakening of CI, we tested the effect of adoptively transferred splenocytes from tumour-bearing mice, untreated or depleted on T-lymphocytes or macrophages, on s.c. tumour growth (EAT) and development of artificial lung metastases (MC). The results indicated that in tumour-bearing mice, T-lymphocytes suppressor effect was more important in the earlier CI weakening period. In the late CI weakening period this role was overtaken by macrophages.

tumour; metastases; concomitant immunity; lymphocytes; macrophages; suppressor effect

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