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Pregled bibliografske jedinice broj: 185879

Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator


Starčević, Kristina; Karminski-Zamola, Grace; Piantanida, Ivo; Žinić, Mladen; Šuman, Lidija; Kralj, Marijeta
Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator // Journal of the American Chemical Society, 127 (2005), 1074-1075 (međunarodna recenzija, članak, znanstveni)


Naslov
Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator

Autori
Starčević, Kristina ; Karminski-Zamola, Grace ; Piantanida, Ivo ; Žinić, Mladen ; Šuman, Lidija ; Kralj, Marijeta

Izvornik
Journal of the American Chemical Society (0002-7863) 127 (2005); 1074-1075

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Amidines; photoinduced anticancer therapy

Sažetak
Spectroscopic titrations and thermal denaturation experiments show that "acyclic" analogue 1 does not bind to ds-DNA but under same conditions "cyclic" 2 strongly interacts with ds-DNA and ds-RNA by intercalation into double helix. Besides, 2 is significantly more effective in inhibition of the tumor cell growth in vitro than 1. We have shown that it is possible to efficiently convert "DNA inactive" compound 1 into "DNA active" compound 2 by light irradiation of the aqueous solutions of the former. This strategy offers a new and attractive approach to photodynamic anticancer therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI