engleski

Changes in serum insulin sensitivity provoked by beta-2-adrenergic agonist clenbuterol

Clenbuterol is a synthetic selective beta-2-adrenergic agonist widely used as a bronchodilator in veterinary and human medicine. When administered in 5-to 10-fold therapeutic dosages, clenbuterol has marked growth promoting effects in slaughter animals, reduces body lipids and promotes muscle growth. Many countries have imposed total ban on the use of clenbuterol for fattening purposes, since its abuse may have adverse effects on animal welfare and on consumer health. Previous reports have shown that administration of clenbuterol to calves for fattening purpose could influence their insulin secretion. The aim of the present study was to determine the possible changes in insulin secretion after acute exposure of female pigs to a growth promoting dose of clenbuterol. A significantly higher (p<0, 001) serum insulin concentration was recorded 30, 60 and 120 min after treatment, as compared to control pigs. After that (180, 240 and 300 min) the concentration of insulin progressively decreased and at 300 min it reached some levels recorded in control animals. The results suggested that acute treatment of female pigs with a growth-promoting dose of clenbuterol influenced the beta cell of the islets of Langerhans in the process of insulin secretion.

clenbuterol; insulin; female pigs

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