engleski

Does increased activity of multidrug transporter predict therapy outcome in patients with Helicobacter pylori infection?

The aim of this study was to determine whether unsuccessful erradication (local antibiotic resistance) involves Pgp mediated active drug out-pumping during Helicobacter (H) pylori infection treatment. H pylori positive patients were compared with the Pgp activity in 12 control subjects with normal endoscopic finding. Pgp activity was determined as mean fluorescence ratio (RMF). During the course of antibiotic therapy, RMF increased (p<0.05) and gastric cells showed higher rhodamine dye efflux. Also the mean pretratment RMF values were higher (p<0.0001) in patients with multiple therapeutic failure than in those with successful H pylori eradication and control subjects. Pgp might be one of the causes of therapy failure.

Pgp; MDR; Helicobacter pylori

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