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Macromolecular prodrugs : VI. kinetic study of poly[alpha, beta-(N-2-hydroxyethyl-DL-aspartamide)]-ketoprofen hydrolysis (CROSBI ID 77557)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jakšić, Planinka ; Mlinarić-Majerski, Kata ; Zorc, Branka ; Dumić, Miljenko Macromolecular prodrugs : VI. kinetic study of poly[alpha, beta-(N-2-hydroxyethyl-DL-aspartamide)]-ketoprofen hydrolysis // International journal of pharmaceutics, 135 (1996), 1-2; 177-182-x

Podaci o odgovornosti

Jakšić, Planinka ; Mlinarić-Majerski, Kata ; Zorc, Branka ; Dumić, Miljenko

engleski

Macromolecular prodrugs : VI. kinetic study of poly[alpha, beta-(N-2-hydroxyethyl-DL-aspartamide)]-ketoprofen hydrolysis

The kinetics of hydrolysis of ketoprofen from poly[alpha, beta-(N-2-hydroxyethyl-DL-aspartamide)]-ketoprofen conjugate (PHEA-Ket) in aqueous buffer solutions in the pH range 1.0-10.6 at 37 degrees C was studied. The hydrolysis of PHEA-Ket conjugate followed the pseudofirst-order kinetic. The following rate constants were obtained: k = 1.542 x 10(-2)h (-1) at pH = 1.0, k = 6.260 x 10(-3) h(-1) at pH = 9.2, and k = 0.155 h(-1) at pH = 10.6. At pH = 5.0 and 7.0 no significant hydrolysis was observed. The PHEA-Ket was also stable after exposure to several enzymatic systems in neutral medium. Determination of ketoprofen was performed by high performance liquid chromatography using diclofenac as the internal standard.

polymeric prodrug; ketoprofen; poly[alpha; beta-(n-2-hydroxyethyl-dl-aspartamide)]; poly[alpha; beta-(n-2-hydroxyethyl-dl-aspartamide)]-ketoprofen conjugate; hydrolysis; enzyme; high performance liquid chromatography

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Podaci o izdanju

135 (1-2)

1996.

177-182-x

objavljeno

0378-5173

Povezanost rada

Kemija

Indeksiranost