engleski

Feasibility, accuracy and safety of late chorionic villus sampling: a report 4600 cases

Objective: The purpose of this article was to evaluate the association between late CVS (placental biopsy) and complications between sampling and delivery. Methods: Late chorionic villus sampling under ultrasound guidance was carried out in 4000 (87, 0 %) cases in the second trimester and 600 (13, 0 %) cases in the third trimester of pregnancy over a sixteenth years period. Out of 4600 late CVS, 765 (16, 6 %) were performed because of suspicious ultrasonographic findings. In the 1100 patients between 13 and 20 weeks of gestation color Doppler was used to investigate the uteroplacental and fetal vessels before and after late chorionic villus sampling. Results: In 40 patients (0, 86 %), complications between sampling and delivery were found. There were only 13 (0, 28 %) spontaneous abortions four to six weeks after late chorionic villus sampling. We found 189 (4, 10 %) chromosomal abnormalities. In the group with suspicious ultrasonic findings (765 cases) we found significant oligohydramnios in 325 (42, 5 %) and significant polyhydramnios in 180 (23, 5 %), and 118 (15, 4 %) had chromosomal abnormalities. Among the 189 patients with chromosomal abnormalities, ultrasonographic findings in 95 (50, 3 %) were detected after 20th week of pregnancy. There were no significant differences in mean pulsatility indices between uteroplacental and fetal vessels before and after late chorionic villus sampling. Preliminary data for thirty trisomic fetuses (twenty trisomy 21, five trisomy 18 and five trisomy 13) indicate an abnormally increased umbilical PI and abnormally decreased middle cerebral artery PI. Conclusions: Late CVS is a safe method of prenatal diagnosis for high-risk couples and does not significantly affect the outcome of pregnancy.

late CVS

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