engleski

The Influence of Stomach Mucosa Morphological Changes on Somatostatin Cell Number in Antrum Mucosa

Background: The aim of this paper was to study and analyze the influence of the different morphological changes on gastric mucosa on somatostatin D-cell number in antral mucosa. Methods: we analyzed according to Sydney classification to what extend the severity of gastritis affect the observed hormonal values. We compared somatostatin D-cell number in antral mucosa between three groups of patients: mild, moderate and severe chronic antral gastritis. Results: the average number of somatostatin cells in biopsy sample of antrum mucosa was 30, 41&plusmn ; ; ; 35, 38 (N=17) in the case of idle form, 18, 69&plusmn ; ; ; 26, 65 (N=65) in moderate and in severe case of chronic gastritis 5, 23&plusmn ; ; ; 5, 93 (N=7) cells in mm2 of mucosa. Conclusion: in order to determine the number of somatostatine cells in antrum mucosa with present morphological changes of mucosa, it might be of help to exclude the patients with non-ulcer dyspepsia, but with the higher risk of premalignant and malignant changes.

Gastritis chr.; Somatostatin; D-cells

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