engleski

Project: Alcohol-related cancer and genetic susceptibility in Europe (ARCAGE)

Great differences in the incidence of upper aerodigestive tract cancers accross Europe cannot be explained by differences in absolute levels of smoking and alcohol consumption. The International Agency for Research on Cancer has launched a multicenter case-control study of uper aerodigestive tract cancer in 13 centres in 9 European countries, Croatia included. By the end of the recruitment period (December 31, 2004), 5000 cases and 5000 controls should be recruited. The Croatian centre (Croatian National Institute of Public Health) is expected to recruit 75 cases and 75 controls. The aim of the project is to assess the role of different environmental and genetic risk factors and their interactions in the etiology of upper aerodigestive tract cancer. A 10-ml blood sample and a lifestyle questionnaire are a minimum requirement for all subjects. Genetic polymorphisms will centrally be tested, using, for this purpose custom designed, DNA-microarray technology. A common database of lifestyle data will be developed for statistical. In Croatia, 35% of subjects have been recruited so far: 26 oral cancer cases, 5 pharyngeal cancer cases and 21 controls. The cases and controls were recruited from University hospital Dubrava and Merkur university hospital, Zagreb. Multicenter international case-control studies with custom designed DNA microarrays provide an opportunity to assess the role of genetic susceptibility as well as environmental factors in the etiology of cancer. Considering the well established pathologic, oncologic and epidemiologic practices, Croatia can provide a valuable contribution to such studies.

upper aerodigestive tract cancers; risk factors; genetic susceptibility; case-control study

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