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Pregled bibliografske jedinice broj: 182450

Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy


Ajdukovic, Radmila; Majdak, Patricia; Bendelja, Krešo; Svoboda-Beusan, Ivna
Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy // Proceeding Book
Opatija, Hrvatska, 2004. str. 67-67 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 182450 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy

Autori
Ajdukovic, Radmila ; Majdak, Patricia ; Bendelja, Krešo ; Svoboda-Beusan, Ivna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceeding Book / - , 2004, 67-67

Skup
Croatian Immunological Society Annual Meeting 2004

Mjesto i datum
Opatija, Hrvatska, 08-10.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Pgp; Multiple myeloma; Idarubicin

Sažetak
Multiple myeloma (MM) is still incurable because the malignant clone resists complete eradication following the treatment. The reason for chemotherapy failure has been associated with the development of multidrug resistance (MDR) and the need for MDR-independent regimens has emerged. In this sense, VID protocol (vincristine, idarubicin, dexamethasone) has been created, using MDR-independent idarubicin instead of the MDR-dependent adriamycin to overcome the effect of the MDR1 gene product P-glycoprotein (Pgp). The purpose of this follow up study was to asses Pgp phenotype and function in bone marrow (BM) cells of MM patients treated according to standard MM chemotherapy protocols, including VID. The Pgp phenotype of BM plasma cells was analyzed using the CD38/CD138/MRK-16 combination and Pgp activity was measured in the rhodamine dye functional efflux assay. Pgp expression on CD38+ cells increased with the advanced clinical stage of the disease, with the strongest Pgp expression in stage III (pI, III<0.01). Pgp expression on CD38/CD138 population increased after both MDR-dependent treatment and VID, but was significantly lower following VID treatment (p<0.01 compared to VAD-treated MM). High percentage of Pgp+ plasmocytes was observed in MM not responding to therapy (p<0.01) and in those with fatal outcome (p<0.05). Furthermore, the BM cells of patients receiving idarubicin-based chemotherapy had lower Pgp activity than VAD or untreated patients. At the clinical level, this indicates that idarubicin may have the ability to suspend Pgp activity thus increasing the intracellular drug concentration. Idarubicin seems to circumvent MDR, however, further studies are needed to evaluate its chemotherapeutic efficacy in the treatment of MM

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0021001

Ustanove:
Imunološki zavod d.d.

Profili:

Avatar Url Ivna Svoboda-Beusan (autor)

Avatar Url Krešo Bendelja (autor)


Citiraj ovu publikaciju

Ajdukovic, Radmila; Majdak, Patricia; Bendelja, Krešo; Svoboda-Beusan, Ivna
Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy // Proceeding Book
Opatija, Hrvatska, 2004. str. 67-67 (poster, nije recenziran, sažetak, znanstveni)
Ajdukovic, R., Majdak, P., Bendelja, K. & Svoboda-Beusan, I. (2004) Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy. U: Proceeding Book.
@article{article, year = {2004}, pages = {67-67}, keywords = {Pgp, Multiple myeloma, Idarubicin}, title = {Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy}, keyword = {Pgp, Multiple myeloma, Idarubicin}, publisherplace = {Opatija, Hrvatska} }
@article{article, year = {2004}, pages = {67-67}, keywords = {Pgp, Multiple myeloma, Idarubicin}, title = {Relevance of Pgp expression and activity in multiple myeloma patients treated with idarubicin-based chemotherapy}, keyword = {Pgp, Multiple myeloma, Idarubicin}, publisherplace = {Opatija, Hrvatska} }




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