engleski

Biochemical changes in rat serum after consumption of ochratoxin A

Ochratoxin A (OA)is mycotoxin found as a contaminant both in food (mainly cereals, dried fruits, coffee and cocoa) and in animal feed. OA is also present in the blood of animals and humans after consumption of contaminated food. Concentrations of OA in blood of helathy people normally ranges from 0.1-14.4 micrograms/L. OA is nephrotoxic, hepatotoxic, genotoxic, teratogenic and carcinogenic agent. The effect of OA was followed in animal model. Rats of Fisher strain were given a daily dose of 120 micrograms OA over 10 to 35 days duration. The changes in blood levels after 10 days of OA application were reflected as a decrease of activities of alkaline phosphatase (48 %) and gamma-glutamyl transferase (50 %) and an increase in urea concentration of 124 %. After 35 days of treatment the values of alkaline phosphatase and gamma-glutamyltransferase were 28 % and 56 % respecitvely. The blood level of OA after 10 days was 115 ng/ml, rising to 194 ng/ml at the end of study.

ochratoxin A; alkaline phosphatase; gamma-glutamyltransferase; urea; rats

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