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Biochemical changes in rat serum after consumption of ochratoxin A


Petrik, Jozsef; Pepeljnjak, Stjepan; Radić, Božica; Lucić, Ana; Paripović, Roberta
Biochemical changes in rat serum after consumption of ochratoxin A // Proceedings of the XVI International Congress of Clinical Chemistry / Martin, M. Susan ; Halloran, P. Stephen (ur.).
London: The Association of Clinical Biochemists, 1996. str. 119-120 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Biochemical changes in rat serum after consumption of ochratoxin A

Autori
Petrik, Jozsef ; Pepeljnjak, Stjepan ; Radić, Božica ; Lucić, Ana ; Paripović, Roberta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the XVI International Congress of Clinical Chemistry / Martin, M. Susan ; Halloran, P. Stephen - London : The Association of Clinical Biochemists, 1996, 119-120

Skup
XVI International Congress of Clinical Chemistry

Mjesto i datum
London, Engleska, 08-12.07.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ochratoxin A; alkaline phosphatase; gamma-glutamyltransferase; urea; rats

Sažetak
Ochratoxin A (OA)is mycotoxin found as a contaminant both in food (mainly cereals, dried fruits, coffee and cocoa) and in animal feed. OA is also present in the blood of animals and humans after consumption of contaminated food. Concentrations of OA in blood of helathy people normally ranges from 0.1-14.4 micrograms/L. OA is nephrotoxic, hepatotoxic, genotoxic, teratogenic and carcinogenic agent. The effect of OA was followed in animal model. Rats of Fisher strain were given a daily dose of 120 micrograms OA over 10 to 35 days duration. The changes in blood levels after 10 days of OA application were reflected as a decrease of activities of alkaline phosphatase (48 %) and gamma-glutamyl transferase (50 %) and an increase in urea concentration of 124 %. After 35 days of treatment the values of alkaline phosphatase and gamma-glutamyltransferase were 28 % and 56 % respecitvely. The blood level of OA after 10 days was 115 ng/ml, rising to 194 ng/ml at the end of study.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
00220106
006311

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb