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Pregled bibliografske jedinice broj: 18073

Stimulation of T-cell proliferation by pancreastatin and its C- terminal fragment (33-49)


Haberstock-Debić, Helena; Banfić, Hrvoje; Stevens, Wim J.; DeClerck, Luc S.; Wechsung, Eleonora; DePotter, Werner
Stimulation of T-cell proliferation by pancreastatin and its C- terminal fragment (33-49) // Neuroimmunomodulation, 4 (1997), 5-6; 244-249 doi:10.1159/000097343 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 18073 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Stimulation of T-cell proliferation by pancreastatin and its C- terminal fragment (33-49)
(Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49))

Autori
Haberstock-Debić, Helena ; Banfić, Hrvoje ; Stevens, Wim J. ; DeClerck, Luc S. ; Wechsung, Eleonora ; DePotter, Werner

Izvornik
Neuroimmunomodulation (1021-7401) 4 (1997), 5-6; 244-249

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pancreastatin ; C-terminal pancreastatin fragment (33-49) ; Lymphocyte proliferation ; Diacylglycerol

Sažetak
We have studied the effect of pancreastatin and its C-terminal fragment (33-49) on mitogen- stimulated T lymphocyte proliferation. In a concentration range from 10-12 to 10-18 M they exhibit a dose dependent stimulatory effect on concanavalin A-induced response with the maximal effect at 10-8 M concentration. They were inactive in response to a B-cell mitogen, lipopolysaccharide, which points to an involvement of T but not B lymphocytes in their response. Pancreastatin can still produce a stimulatory effect when added 18h after incubation of cultures with concanavalin A and apparently uses a diacylglycerol independent mechanism. When cells were preincubated for 4, 16 or 24h with pancreastatin or its fragment and than stimulated with concanavalin A, a ten times lower concentration of peptides was needed (10-9 M) to obtain the maximal response. This suggests that resting cells are more sensitive to pancreastatin and its fragment. Both peptides exhibit a very similar pharmacological profile, indicating that the C- terminal part of the molecule is responsible for the effect on T-cell proliferation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
00981107

Ustanove:
Institut "Ruđer Bošković", Zagreb

doi

Citiraj ovu publikaciju

Haberstock-Debić, Helena; Banfić, Hrvoje; Stevens, Wim J.; DeClerck, Luc S.; Wechsung, Eleonora; DePotter, Werner
Stimulation of T-cell proliferation by pancreastatin and its C- terminal fragment (33-49) // Neuroimmunomodulation, 4 (1997), 5-6; 244-249 doi:10.1159/000097343 (međunarodna recenzija, članak, znanstveni)
Haberstock-Debić, H., Banfić, H., Stevens, W., DeClerck, L., Wechsung, E. & DePotter, W. (1997) Stimulation of T-cell proliferation by pancreastatin and its C- terminal fragment (33-49). Neuroimmunomodulation, 4 (5-6), 244-249 doi:10.1159/000097343.
@article{article, year = {1997}, pages = {244-249}, DOI = {10.1159/000097343}, keywords = {Pancreastatin, C-terminal pancreastatin fragment (33-49), Lymphocyte proliferation, Diacylglycerol}, journal = {Neuroimmunomodulation}, doi = {10.1159/000097343}, volume = {4}, number = {5-6}, issn = {1021-7401}, title = {Stimulation of T-cell proliferation by pancreastatin and its C- terminal fragment (33-49)}, keyword = {Pancreastatin, C-terminal pancreastatin fragment (33-49), Lymphocyte proliferation, Diacylglycerol} }
@article{article, year = {1997}, pages = {244-249}, DOI = {10.1159/000097343}, keywords = {Pancreastatin, C-terminal pancreastatin fragment (33-49), Lymphocyte proliferation, Diacylglycerol}, journal = {Neuroimmunomodulation}, doi = {10.1159/000097343}, volume = {4}, number = {5-6}, issn = {1021-7401}, title = {Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49)}, keyword = {Pancreastatin, C-terminal pancreastatin fragment (33-49), Lymphocyte proliferation, Diacylglycerol} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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