engleski

Uric acid inhibits glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic b-cells

Uric acid (1a) suppresses basal insulin release in isolated rat pancreatic islets, and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (>0.4 mM). Conversely, 1 mM guanidinium urate (2a) was completely ineffective, strongly suggesting that binding to an essential arginine residue triggers the inhibitory effect. A specific recognition of 1a molecule at the crucial beta-cell receptor is probably involved in the blocking glucose signal transduction.

uric acid; purines; beta-cell; pancreatic islets; guanidinium urate; arginine residue; glucose-stimulated insulin secretion; uricase

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